Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8254835 | 0.79 | HDAC1 (0.56) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL8255178 | 0.79 | HDAC1 (0.53) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL8256889 | 0.79 | HDAC1 (0.53) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL8256234 | 0.79 | HDAC1 (0.56) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL8257577 | 0.77 | HDAC1 (0.56) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL8248135 | 0.75 | HDAC1 (0.52) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL2510469 | 0.73 | HDAC1 (1.00) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL2510471 | 0.73 | HDAC1 (1.00) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL8248130 | 0.72 | HDAC1 (0.56) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL3368462 | 0.71 | HDAC1 (1.00) | HDAC1HDAC8HDAC6HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006101456-A1 | BICYCLIC HETEROCYCLES HYDROXAMATE COMPOUNDS USEFUL AS HISTONE DEACETYLASE (HDAC) INHIBITORS | S*BIO PTE LTD (SG) | 2006-09-28 | — | — | WO | disclosed |