Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5253850 | 0.94 | POLA1 (0.57) | POLA1ROCK2MAPTPOLBGAA | |
| SCHEMBL13115515 | 0.88 | ROCK2 (0.53) | POLA1ROCK2MAPTPOLBGAA | |
| SCHEMBL3364603 | 0.84 | ROCK2 (0.56) | POLA1ROCK2MAPTPOLBGAA | |
| SCHEMBL5256438 | 0.82 | ROCK2 (0.71) | POLA1ROCK2MAPTPOLBGAA | |
| SCHEMBL5253438 | 0.82 | ROCK2 (0.61) | POLA1ROCK2CYP3A4AGPAT2ROCK1 | |
| SCHEMBL10036353 | 0.82 | POLA1 (0.61) | POLA1ROCK2MAPTPOLBGAA | |
| SCHEMBL724445 | 0.78 | AGPAT2 (0.58) | ROCK2MAPTKMT2AAGPAT2AURKA | |
| SCHEMBL10036354 | 0.77 | ROCK2 (0.68) | POLA1ROCK2OPRK1CYP3A4AGPAT2 | |
| SCHEMBL10305603 | 0.77 | ROCK2 (0.40) | POLA1ROCK2MAPTPOLBGAA | |
| SCHEMBL10036314 | 0.76 | ROCK2 (0.52) | ROCK2MAPTKMT2AMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470122-B1 | RHO-KINASE INHIBITORS | BAYER PHARMACEUTICALS CORP (US) | 2007-12-19 | — | — | EP | disclosed |