Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.89 |
| ▸ | KDR | P35968 | 7/20 | 0.89 |
| ▸ | PRKCQ | Q04759 | 7/20 | 0.89 |
| ▸ | FLT3 | P36888 | 5/20 | 0.89 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.89 |
| ▸ | PRKCA | P17252 | 5/20 | 0.89 |
| ▸ | PRKCH | P24723 | 5/20 | 0.89 |
| ▸ | PRKCI | P41743 | 5/20 | 0.89 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.89 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.89 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.89 |
| ▸ | MYLK | Q15746 | 4/20 | 0.89 |
| ▸ | CDK4 | P11802 | 3/20 | 0.89 |
| ▸ | CDK2 | P24941 | 3/20 | 0.89 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.89 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.89 |
| ▸ | JAK2 | O60674 | 2/20 | 0.89 |
| ▸ | PLK4 | O00444 | 2/20 | 0.89 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.89 |
| ▸ | AURKA | O14965 | 2/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13524747 | 1.00 | NTRK1 (0.89) | NTRK1KDRPRKCQFLT3PRKD3 | |
| Lestaurtinib SCHEMBL12963759 | 0.94 | NTRK1 (1.00) | NTRK1KDRPRKCQFLT3PRKD3 | |
| Lestaurtinib SCHEMBL29625224 | 0.94 | NTRK1 (1.00) | NTRK1KDRPRKCQFLT3PRKD3 | |
| Lestaurtinib SCHEMBL1649693 | 0.94 | NTRK1 (1.00) | NTRK1KDRPRKCQFLT3PRKD3 | |
| Lestaurtinib SCHEMBL17971367 | 0.94 | NTRK1 (1.00) | NTRK1KDRPRKCQFLT3PRKD3 | |
| Lestaurtinib SCHEMBL17971365 | 0.94 | NTRK1 (1.00) | NTRK1KDRPRKCQFLT3PRKD3 | |
| Lestaurtinib SCHEMBL12228516 | 0.94 | NTRK1 (1.00) | NTRK1KDRPRKCQFLT3PRKD3 | |
| Lestaurtinib SCHEMBL16139562 | 0.94 | NTRK1 (1.00) | NTRK1KDRPRKCQFLT3PRKD3 | |
| Lestaurtinib SCHEMBL13169434 | 0.94 | NTRK1 (1.00) | NTRK1KDRPRKCQFLT3PRKD3 | |
| Lestaurtinib SCHEMBL730955 | 0.94 | NTRK1 (1.00) | NTRK1KDRPRKCQFLT3PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070281907-A1 | Kinase Inhibitor Phosphonate Conjugates | GILEAD SCIENCES, INC. | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281907-A1 | Kinase Inhibitor Phosphonate Conjugates | PIK3CA, PNKP, PLK1 | NTRK1 755/4885KDR 593/4885PRKCQ 131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.