Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lestaurtinib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 known ✓ | P04629 | 10/20 | 1.00 |
| ▸ | FLT3 known ✓ | P36888 | 5/20 | 1.00 |
| ▸ | JAK2 known ✓ | O60674 | 2/20 | 1.00 |
| ▸ | RET known ✓ | P07949 | 2/20 | 1.00 |
| ▸ | NTRK3 known ✓ | Q16288 | 1/20 | 1.00 |
| ▸ | NTRK2 known ✓ | Q16620 | 1/20 | 1.00 |
| ▸ | KDR | P35968 | 9/20 | 1.00 |
| ▸ | PRKCQ | Q04759 | 7/20 | 1.00 |
| ▸ | PRKD3 | O94806 | 5/20 | 1.00 |
| ▸ | PRKCA | P17252 | 5/20 | 1.00 |
| ▸ | PRKCH | P24723 | 5/20 | 1.00 |
| ▸ | PRKCI | P41743 | 5/20 | 1.00 |
| ▸ | PRKCE | Q02156 | 5/20 | 1.00 |
| ▸ | PRKCD | Q05655 | 5/20 | 1.00 |
| ▸ | PRKD1 | Q15139 | 5/20 | 1.00 |
| ▸ | MYLK | Q15746 | 4/20 | 1.00 |
| ▸ | CDK4 | P11802 | 3/20 | 1.00 |
| ▸ | CDK2 | P24941 | 3/20 | 1.00 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 1.00 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lestaurtinib SCHEMBL16139562 | 1.00 | NTRK1 (1.00) | NTRK1KDRPRKCQFLT3PRKD3 | |
| Lestaurtinib SCHEMBL1649693 | 1.00 | NTRK1 (1.00) | NTRK1KDRPRKCQFLT3PRKD3 | |
| Lestaurtinib SCHEMBL12228516 | 1.00 | NTRK1 (1.00) | NTRK1KDRPRKCQFLT3PRKD3 | |
| Lestaurtinib SCHEMBL29625224 | 1.00 | NTRK1 (1.00) | NTRK1KDRPRKCQFLT3PRKD3 | |
| Lestaurtinib SCHEMBL17971367 | 1.00 | NTRK1 (1.00) | NTRK1KDRPRKCQFLT3PRKD3 | |
| Lestaurtinib SCHEMBL17971365 | 1.00 | NTRK1 (1.00) | NTRK1KDRPRKCQFLT3PRKD3 | |
| Lestaurtinib SCHEMBL12963759 | 1.00 | NTRK1 (1.00) | NTRK1KDRPRKCQFLT3PRKD3 | |
| Lestaurtinib SCHEMBL13169434 | 1.00 | NTRK1 (1.00) | NTRK1KDRPRKCQFLT3PRKD3 | |
| Lestaurtinib SCHEMBL30149252 | 0.99 | NTRK1 (0.98) | NTRK1KDRPRKCQFLT3PRKD3 | |
| SCHEMBL14342269 | 0.94 | NTRK1 (0.89) | NTRK1KDRPRKCQFLT3PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260132164-A1 | PNU ANTHRACYCLINE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME LLC (US) | 2026-05-14 | — | — | US | disclosed |
| EP-4076459-B1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2026-04-29 | — | — | EP | disclosed |
| US-12595262-B2 | PRMT5 inhibitors | MERCK SHARP & DOHME LLC (US) | 2026-04-07 | — | — | US | disclosed |
| US-12595248-B2 | PRMT5 inhibitors | MERCK SHARP & DOHME LLC (US) | 2026-04-07 | — | — | US | disclosed |
| US-12583871-B2 | PRMT5 inhibitors | MERCK SHARP & DOHME LLC (US) | 2026-03-24 | — | — | US | disclosed |
| US-12552826-B2 | PRMT5 inhibitors | MERCK SHARP & DOHME LLC (US) | 2026-02-17 | — | — | US | disclosed |
| EP-4076460-B1 | 1,4-DIHYDRO-2H-SPIRO[ISOQUINOLINE-3,4'-PIPERIDINE DERIVATIVES AS PRMT5 INHIBITORS FOR THE TREATMENT OF CANCER | MERCK SHARP & DOHME LLC (US) | 2026-01-21 | — | — | EP | disclosed |
| US-20260000691-A1 | COMPOUNDS, METHODS, AND TREATMENTS FOR ABNORMAL SIGNALING PATHWAYS FOR PRENATAL AND POSTNATAL DEVELOPMENT | JENNINGS BARBARA BROOKE (US) | 2026-01-01 | — | — | US | disclosed |
| US-12486503-B2 | Short interfering nucleic acid (siNA) compositions | SIRNA THERAPEUTICS, INC. (US) | 2025-12-02 | — | — | US | disclosed |
| US-12441730-B2 | PRMT5 inhibitors | MERCK SHARP & DOHME LLC (US) | 2025-10-14 | — | — | US | disclosed |
| EP-1503757-A2 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2005-02-09 | — | — | EP | disclosed |
| EP-1496906-A1 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2005-01-19 | — | — | EP | disclosed |
| EP-1494676-A1 | FUSED QUINOXALINE DERIVATIVES AS INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | disclosed |
| EP-1226136-B1 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2004-12-29 | — | — | EP | disclosed |
| EP-1481077-A2 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003106417-A1 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2003-12-24 | — | — | WO | disclosed |
| WO-2003092595-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC (US) | 2003-11-13 | — | — | WO | disclosed |
| WO-2003086403-A1 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | disclosed |
| WO-2003086404-A1 | FUSED QUINOXALINE DERIVATIVES AS INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | disclosed |
| WO-2003049679-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2003-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12595248-B2 | PRMT5 inhibitors | PRMT5, PRMT1, PRMT6 | NTRK1 4308/4885FLT3 660/4885JAK2 1058/4885 |
| US-20260000691-A1 | COMPOUNDS, METHODS, AND TREATMENTS FOR ABNORMAL SIGNALING PATHWAYS FOR PRENATAL AND POSTNATAL DEVELOPMENT | PDK1, IP6K1, IP6K3 | NTRK1 3062/4885FLT3 1106/4885JAK2 2308/4885 |
| US-12595262-B2 | PRMT5 inhibitors | PRMT1, PRMT5, CARM1 | NTRK1 4568/4885FLT3 290/4885JAK2 10/4885 |
| US-20260132164-A1 | PNU ANTHRACYCLINE DERIVATIVES AND METHODS OF USE THEREOF | TOP1, NCL, NOLC1 | NTRK1 941/4885FLT3 2377/4885JAK2 1295/4885 |
| US-12441730-B2 | PRMT5 inhibitors | PRMT5, PRMT1, PRMT3 | NTRK1 4854/4885FLT3 194/4885JAK2 741/4885 |
| US-12583871-B2 | PRMT5 inhibitors | PRMT5, PRMT1, PRMT3 | NTRK1 4618/4885FLT3 901/4885JAK2 287/4885 |
| US-12552826-B2 | PRMT5 inhibitors | PRMT5, PRMT6, PRMT1 | NTRK1 4546/4885FLT3 484/4885JAK2 959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.