Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14343558 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL14342816 | 0.92 | EPHX1 (0.50) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL14342713 | 0.92 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL14343496 | 0.88 | EPHX1 (0.54) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL14343663 | 0.88 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL14342803 | 0.88 | EPHX1 (0.54) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL14343846 | 0.86 | NPC1 (0.51) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL14343810 | 0.84 | SMN1; SMN2 (0.38) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL14343570 | 0.82 | EPHX1 (0.61) | SMN1; SMN2ALDH1A1EPHX2EPHX1 | |
| SCHEMBL14343158 | 0.82 | EPHX1 (0.61) | SMN1; SMN2NPC1RAB9AALDH1A1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007150011-A2 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-12-27 | — | — | WO | disclosed |