Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 8/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14343558 | 0.88 | SMN1; SMN2 (0.50) | EPHX1KMT2AKDM4ENPC1MAPT | |
| SCHEMBL14343076 | 0.88 | SMN1; SMN2 (0.50) | EPHX1KMT2AKDM4ENPC1MAPT | |
| SCHEMBL14342816 | 0.81 | EPHX1 (0.50) | EPHX1KMT2ANPC1MAPTRAB9A | |
| SCHEMBL14342713 | 0.81 | SMN1; SMN2 (0.42) | EPHX1HPGDKMT2ANPC1MAPT | |
| SCHEMBL14343158 | 0.78 | EPHX1 (0.61) | EPHX1HPGDKMT2ANPC1RAB9A | |
| SCHEMBL14343664 | 0.78 | EPHX1 (0.55) | EPHX1HPGDKMT2ANPC1MAPT | |
| SCHEMBL14343663 | 0.78 | SMN1; SMN2 (0.39) | EPHX1KMT2ANPC1MAPTRAB9A | |
| SCHEMBL14342803 | 0.78 | EPHX1 (0.54) | EPHX1KMT2AKDM4ENPC1MAPT | |
| SCHEMBL14343846 | 0.75 | NPC1 (0.51) | EPHX1HPGDKMT2ANPC1MAPT | |
| SCHEMBL14343795 | 0.75 | RAB9A (0.62) | EPHX1HPGDKMT2ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007150011-A2 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-12-27 | — | — | WO | disclosed |