Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 4/20 | 0.46 |
| ▸ | CDK2 | P24941 | 7/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.44 |
| ▸ | CCNH | P51946 | 3/20 | 0.44 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.44 |
| ▸ | CDK9 | P50750 | 6/20 | 0.42 |
| ▸ | CDK1 | P06493 | 4/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14346525 | 0.90 | CDK2 (0.41) | TTKCYP3A4CDK7CDK2CCNE1 | |
| SCHEMBL14346520 | 0.83 | CDK7 (0.41) | TTKCYP3A4CDK7CDK2CCNE1 | |
| SCHEMBL14346497 | 0.83 | CDK7 (0.41) | TTKCYP3A4CDK7CDK2CCNE1 | |
| SCHEMBL14346522 | 0.82 | CDK2 (0.41) | TTKCYP3A4CDK7CDK2CCNE1 | |
| SCHEMBL14545919 | 0.81 | GSK3B (0.54) | TTKCYP3A4CDK7CDK2CCNE1 | |
| SCHEMBL12953797 | 0.81 | CDK2 (0.49) | TTKCYP3A4CDK7CDK2CCNE1 | |
| SCHEMBL14346499 | 0.81 | GSK3B (0.43) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL13305360 | 0.80 | GSK3B (0.54) | TTKCYP3A4CDK7CDK2CCNE1 | |
| SCHEMBL12954566 | 0.78 | CDK2 (0.45) | TTKCDK7CDK2CCNE1CCNH | |
| SCHEMBL14346161 | 0.78 | GSK3B (0.48) | CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007139732-A1 | PYRAZOLO [1, 5-A] PYRIMIDINES AS CDK INHIBITORS | SCHERING CORPORATION (US) | 2007-12-06 | — | — | WO | disclosed |