Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1279903 | 0.80 | HCAR2 (0.52) | HCAR2SLC6A3ALDH1A1SMN1; SMN2RECQL | |
| SCHEMBL25564576 | 0.76 | HCAR2 (0.47) | HCAR2SLC6A3ALDH1A1SMN1; SMN2ERCC5 | |
| SCHEMBL14549193 | 0.76 | SMN1; SMN2 (0.51) | HCAR2SLC6A3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16793195 | 0.74 | SMN1; SMN2 (0.46) | HCAR2SLC6A3ALDH1A1SMN1; SMN2RECQL | |
| SCHEMBL1107383 | 0.74 | — | — | |
| SCHEMBL128429 | 0.74 | — | — | |
| SCHEMBL13142435 | 0.73 | SLC6A3 (0.43) | HCAR2SLC6A3ALDH1A1RECQLERCC5 | |
| SCHEMBL18673935 | 0.73 | SLC6A3 (0.43) | HCAR2SLC6A3ALDH1A1SMN1; SMN2RECQL | |
| SCHEMBL11561896 | 0.72 | POLB (0.39) | HCAR2SLC6A3ALDH1A1SMN1; SMN2RECQL | |
| SCHEMBL25562760 | 0.72 | HCAR2 (0.43) | HCAR2SLC6A3ALDH1A1SMN1; SMN2ERCC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007149512-A2 | PEPTIDE EPOXYKETONES FOR PR0TEAS0ME INHIBITION | PROTEOLIX, INC. (US) | 2007-12-27 | — | — | WO | disclosed |