Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 9/20 | 0.59 |
| ▸ | SRC | P12931 | 6/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | BCR | P11274 | 7/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.58 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.56 |
| ▸ | PRKCA | P17252 | 5/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | PRKCG | P05129 | 1/20 | 0.55 |
| ▸ | PRKCB | P05771 | 1/20 | 0.55 |
| ▸ | PRKCH | P24723 | 1/20 | 0.55 |
| ▸ | PRKCI | P41743 | 1/20 | 0.55 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.55 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.55 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.55 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14348428 | 0.85 | NAMPT (0.57) | NAMPTCSNK2A1CYP3A4KMT2AMKNK1 | |
| SCHEMBL8352521 | 0.79 | ABL1 (0.58) | ABL1SRCEGFRBCRPRKCA | |
| SCHEMBL21858046 | 0.78 | CYP3A4 (0.67) | NAMPTCYP3A4KMT2A | |
| SCHEMBL19303133 | 0.77 | KMT2A (0.67) | NAMPTCYP3A4KMT2A | |
| SCHEMBL5379812 | 0.76 | ABL1 (0.77) | ABL1SRCEGFRBCRPRKCA | |
| SCHEMBL1394015 | 0.75 | NAMPT (0.70) | NAMPTCYP3A4KMT2AGSK3B | |
| SCHEMBL8349452 | 0.75 | JAK2 (0.61) | ABL1SRCEGFRBCRPRKCA | |
| SCHEMBL8349712 | 0.75 | ABL1 (0.53) | ABL1SRCEGFRBCRPRKCA | |
| SCHEMBL8351175 | 0.74 | HPGD (0.54) | ABL1SRCEGFRBCRPRKCA | |
| SCHEMBL6258131 | 0.74 | ABL1 (1.00) | ABL1SRCEGFRBCRPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |