Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.77 |
| ▸ | PRKCA | P17252 | 4/20 | 0.77 |
| ▸ | BCR | P11274 | 4/20 | 0.77 |
| ▸ | CAMK2D | Q13557 | 5/20 | 0.76 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.73 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.73 |
| ▸ | GSK3B | P49841 | 2/20 | 0.73 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.73 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.64 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | SRC | P12931 | 3/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.64 |
| ▸ | PRKCG | P05129 | 1/20 | 0.64 |
| ▸ | PRKCB | P05771 | 1/20 | 0.64 |
| ▸ | PRKCH | P24723 | 1/20 | 0.64 |
| ▸ | PRKCI | P41743 | 1/20 | 0.64 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25337094 | 0.88 | ABL1 (0.75) | ABL1PRKCABCRCAMK2DMAPK8 | |
| SCHEMBL31118910 | 0.88 | ABL1 (0.75) | ABL1PRKCABCRCAMK2DMAPK8 | |
| SCHEMBL1655099 | 0.87 | ABL1 (1.00) | ABL1PRKCABCRCAMK2DMAPK8 | |
| SCHEMBL27115954 | 0.87 | ABL1 (0.74) | ABL1PRKCABCRCAMK2DMAPK8 | |
| SCHEMBL4902223 | 0.86 | ABL1 (0.80) | ABL1PRKCABCRCAMK2DMAPK8 | |
| SCHEMBL4376512 | 0.86 | PLK1 (0.72) | ABL1PRKCABCRCAMK2DMAPK8 | |
| SCHEMBL4897053 | 0.85 | ABL1 (0.71) | ABL1PRKCABCRCAMK2DMAPK8 | |
| SCHEMBL3758823 | 0.85 | MAPK8 (0.76) | ABL1PRKCABCRCAMK2DMAPK8 | |
| SCHEMBL7463871 | 0.84 | ABL1 (0.70) | ABL1PRKCABCRCAMK2DMAPK8 | |
| SCHEMBL31119008 | 0.84 | PLK1 (0.74) | ABL1PRKCABCRCAMK2DMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304071-B2 | Protein kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-04 | — | — | US | disclosed |
| CN-1863780-A | Protein kinase inhibitor and application thereof | VERTEX PHARMA (US) | 2006-11-15 | — | — | CN | disclosed |
| EP-1546117-A2 | PROTEIN KINASE INHIBITORS AND USES THEREOF | Vertex Pharmaceuticals Incorporated (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20040106615-A1 | Protein kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2004-06-03 | — | — | US | disclosed |
| WO-2004016597-A2 | PROTEIN KINASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106615-A1 | Protein kinase inhibitors and uses thereof | JAK1, RAF1, PRKCQ | ABL1 367/4885PRKCA 14/4885BCR 1731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.