Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | JAK3 | P52333 | 2/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4003588 | 0.85 | AURKA (0.55) | AURKAJAK2JAK3 | |
| SCHEMBL14348407 | 0.79 | CAMK2D (0.72) | JAK2JAK3MAPK1EGFRROCK2 | |
| SCHEMBL8351194 | 0.78 | MAPK14 (0.55) | JAK2JAK3MAPK1JAK1TYK2 | |
| SCHEMBL14348413 | 0.78 | CCNA2 (0.55) | CCNA2CDK2CCNA1AURKAEGFR | |
| SCHEMBL14348411 | 0.75 | GRM5 (0.56) | JAK2JAK3MAPK1EGFRBTK | |
| SCHEMBL4559030 | 0.74 | JAK2 (0.54) | JAK2JAK3JAK1TYK2GSK3B | |
| SCHEMBL10974957 | 0.73 | JAK2 (0.53) | CCNA2CDK2AURKAJAK2JAK3 | |
| SCHEMBL14021084 | 0.72 | CAMK2D (0.62) | JAK2JAK3CNR2MAPK1ROCK2 | |
| SCHEMBL22097760 | 0.72 | JAK2 (0.64) | CDK2AURKAJAK2JAK3MAPK1 | |
| SCHEMBL22114912 | 0.72 | JAK2 (0.48) | JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |