Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.31 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8427664 | 1.00 | ACACB (0.33) | ACACBTDP1RENCYP2C9CYP1A2 | |
| SCHEMBL14348285 | 0.96 | METAP2 (0.38) | RENMETAP2ALDH1A1CTSSCTSK | |
| SCHEMBL13359678 | 0.96 | METAP2 (0.38) | RENMETAP2ALDH1A1CTSSCTSK | |
| SCHEMBL8427666 | 0.96 | METAP2 (0.38) | RENMETAP2ALDH1A1CTSSCTSK | |
| SCHEMBL14348134 | 0.96 | METAP2 (0.38) | RENMETAP2ALDH1A1CTSSCTSK | |
| SCHEMBL14348288 | 0.96 | METAP2 (0.35) | ACACBRENMETAP2ALDH1A1MAPK1 | |
| SCHEMBL8426458 | 0.96 | METAP2 (0.35) | ACACBRENMETAP2ALDH1A1MAPK1 | |
| SCHEMBL14348289 | 0.94 | METAP2 (0.38) | RENMETAP2ALDH1A1CPB2ABL1 | |
| SCHEMBL13359716 | 0.94 | METAP2 (0.38) | RENMETAP2ALDH1A1CPB2ABL1 | |
| SCHEMBL14374472 | 0.93 | METAP2 (0.38) | RENMETAP2ALDH1A1CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304049-B2 | Succinoylaminobenzodiazepines as inhibitors of Aβ protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-12-04 | — | — | US | disclosed |