Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 6/20 | 0.46 |
| ▸ | FYN | P06241 | 2/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.40 |
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14349666 | 0.91 | MAPK1 (0.42) | MAPK1FYNHCAR3PRKAB2PRKAG1 | |
| SCHEMBL7864000 | 0.89 | HCAR3 (0.51) | HCAR3CDK2CYP11B1CYP11B2PRKAB2 | |
| SCHEMBL14349199 | 0.86 | HCAR3 (0.54) | HCAR3CYP11B1CYP11B2PRKAB2PRKAG1 | |
| SCHEMBL14349202 | 0.84 | HCAR3 (0.53) | HCAR3CYP11B1CYP11B2PRKAB2PRKAG1 | |
| SCHEMBL26702799 | 0.84 | HCAR3 (0.41) | MAPK1HCAR3CYP11B1CYP11B2PRKAB2 | |
| SCHEMBL15247187 | 0.81 | SYK (0.43) | MAPK1HCAR3CDK2CYP11B1CYP11B2 | |
| SCHEMBL13149122 | 0.80 | MAPK1 (0.63) | MAPK1FYNHCAR3MKNK1MAPK3 | |
| SCHEMBL19117546 | 0.80 | MAPK1 (0.68) | MAPK1MAPK8MAPK9MAPK10HDAC3 | |
| SCHEMBL14924061 | 0.79 | JAK1 (0.45) | MAPK1HCAR3CYP11B1CYP11B2PRKAB2 | |
| SCHEMBL21297272 | 0.78 | MAPK14 (0.52) | MAPK1FYNMKNK1MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312209-B2 | Acridone inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-25 | — | — | US | disclosed |