Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 14/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14349710 | 0.93 | HCAR2 (0.63) | HCAR2KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14349702 | 0.88 | HCAR2 (0.66) | HCAR2KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14349698 | 0.86 | HCAR2 (0.60) | HCAR2KDM4ECYP2C9KMT2AMEN1 | |
| SCHEMBL6781577 | 0.79 | KMT2A (0.58) | HCAR2KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14349711 | 0.78 | HCAR2 (0.86) | HCAR2CYP2C9 | |
| SCHEMBL14349720 | 0.76 | HCAR2 (1.00) | HCAR2CYP2C9 | |
| SCHEMBL14349766 | 0.75 | HCAR2 (0.52) | HCAR2KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14349718 | 0.75 | KDM4E (0.51) | HCAR2KDM4EKMT2AMEN1CASP3 | |
| SCHEMBL14349707 | 0.75 | HCAR2 (0.70) | HCAR2KDM4ECYP2C9KMT2AMEN1 | |
| SCHEMBL14349745 | 0.74 | HCAR2 (0.73) | HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299101-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | MERCK SHARP & DOHME CORP. | 2007-12-27 | — | — | US | disclosed |
| US-20070299101-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | MERCK SHARP & DOHME CORP. | 2007-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299101-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | LDLR, APOB, FFAR1 | HCAR2 20/4885KDM4E 4792/4885NPC1 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.