APOB — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL6498482	0.69	18/20
SCHEMBL6491055	0.60	16/20
SCHEMBL6674528	0.77	15/20
SCHEMBL6678706	0.77	15/20
SCHEMBL2990416	0.67	15/20
SCHEMBL4785948	1.00	14/20
SCHEMBL692958	0.60	14/20
SCHEMBL6500016	0.56	14/20
SCHEMBL4990493	0.51	14/20
SCHEMBL6198258	0.72	13/20
SCHEMBL6218750	0.72	13/20
SCHEMBL6200460	0.67	13/20
SCHEMBL6201381	0.67	12/20
SCHEMBL3288828	0.65	12/20
SCHEMBL6673949	0.63	12/20
SCHEMBL3288697	0.56	12/20
SCHEMBL4075186	0.55	12/20
SCHEMBL4077204	0.51	12/20
SCHEMBL6664137	0.47	12/20
SCHEMBL6667139	0.46	12/20

Clinical trials — most relevant to APOB by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effectiveness of Treatment of Hypercholesterolemia With Rosuvastatin and Ezetimibe	PHASE4	COMPLETED
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ISIS-APO(a)Rx in Participants With High Lipoprotein(a)	PHASE2	COMPLETED
Effects of Different Fish Oil Types on Type 2 Diabetes Risk Factors in High-Risk Adults	PHASE2	NOT_YET_RECRUITING
Oleanolic Acid as Therapeutic Adjuvant for Type 2 Diabetes Mellitus (OLTRAD STUDY)	PHASE2	ACTIVE_NOT_RECRUITING
Pharmacodynamic Biomarkers to Support Biosimilar Development: PCSK9 Inhibitors	PHASE1	COMPLETED
Fat Metabolism in Response to Acute Diet- and Exercise-induced Changes in Energy Balance	nan	COMPLETED
Mechanisms of Low Levels of Apolipoprotein B	nan	COMPLETED
Metabolism of Fibrinogen and Apolipoprotein B-100 in Childhood Obesity and Cardiovascular Disease	nan	COMPLETED
Advanced Lipoproptein Profiling and Cardiovascular Risk Stratification in Familial Hypercholesterolemia	nan	UNKNOWN
Hyperapo B and Coronary Heart Disease	nan	COMPLETED
Efficacy of Lipid-Lowering Therapy Based on Apolipoprotein B Versus LDL-Cholesterol Levels in Patients Undergoing Percutaneous Coronary Intervention	nan	NOT_YET_RECRUITING
Effects of Chitin-Glucan on Oxidized Low-Density Lipoprotein (LDL)	nan	COMPLETED
Role of LipoprotEin(a) in CardiovascuLar Diseases and Premature Acute Coronary Syndromes - (RELACS) Study	nan	UNKNOWN
Studies of Apolipoprotein Genotyping on the Drug Treatment of Hyperlipidemic Patients	nan	COMPLETED
Biomarker for Homozygous Familial Hypercholesterolemia (BioHoFH)	nan	WITHDRAWN
The Roles of SAH Gene Family in Athrogenic Dyslipidemia in Postmenopausal Women	nan	UNKNOWN
Influence of Simvastatin on Apolipoprotein B-100 (apoB-100) Secretion	nan	COMPLETED
Cardiac Biomarkers in Preeclampsia: Prediction of Disease and the Risk of Future Cardiovascular Events in Survivors	nan	UNKNOWN
VLDL and LDL Particle Types as Coronary Heart Disease Risk Factors	nan	COMPLETED
Erythrocyte-bound Apolipoprotein B After Withdrawal of Statin Therapy	nan	COMPLETED
Apolipoprotein A-I Gene Polymorphism and Atherosclerosis	nan	COMPLETED
Prospective Assessment of Atherosclerotic Cardiovascular Disease (ASCVD) Risk	nan	UNKNOWN
Intestines and Liver Contribution to Fasting Postprandial Hypertriglyceridemia	nan	COMPLETED
Effects of Amino Acid Supplementation on Liver Lipid Content and Protein Metabolism in Obese Children	nan	WITHDRAWN
Effect of a Black Garlic Extract on Cholesterol LDL Levels	nan	COMPLETED
Comparison of LDL Particle Count With Other Available Lipid Tests	nan	UNKNOWN
Epidemiology of Genetic Factors in Lipid Metabolism	nan	COMPLETED
OmniHeart Trial: Macronutrients and Cardiovascular Risk	nan	COMPLETED
The Association of SAA With Apolipoprotein B Affects Cardiovascular Risk	nan	COMPLETED
Abnormal Lipids - Causes and Effects	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a APOB binder may also engage these)

Protein	Name	Similarity
Q7TMA5	—	1.000	Q7TMA5 →
A0A0R4IVV0	—	1.000	A0A0R4IVV0 →
P55156	—	1.000	P55156 →
Q865F1	—	1.000	Q865F1 →
E9Q414	—	0.999	E9Q414 →
P55158	—	0.998	P55158 →
A0A0N6WHT4	—	0.992	A0A0N6WHT4 →
Q9U943	—	0.992	Q9U943 →
P18948	—	0.992	P18948 →
MTTP	Microsomal triglyceride transfer protein large subunit	0.992	landscape →
O08601	—	0.990	O08601 →
G5ECG7	—	0.989	G5ECG7 →
Q9VIH3	—	0.989	Q9VIH3 →
Q9N4J2	—	0.988	Q9N4J2 →
D4A1W8	—	0.988	D4A1W8 →
Q98893	—	0.987	Q98893 →
Q90243	—	0.987	Q90243 →
Q2VQM5	—	0.987	Q2VQM5 →
P06125	—	0.987	P06125 →
Q7Z1M0	—	0.987	Q7Z1M0 →
P05690	—	0.986	P05690 →
Q05808	—	0.986	Q05808 →
P87498	—	0.986	P87498 →
Q91062	—	0.986	Q91062 →
P18947	—	0.985	P18947 →
P18709	—	0.985	P18709 →
Q868N5	—	0.985	Q868N5 →
P02845	—	0.984	P02845 →
Q61114	—	0.983	Q61114 →
Q2QLA9	—	0.983	Q2QLA9 →