Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.70 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14349875 | 0.93 | HCAR2 (0.81) | HCAR2CYP2C9CYP2C8KDM4EKMT2A | |
| SCHEMBL14349872 | 0.88 | HCAR2 (0.56) | HCAR2CYP2C9CYP2C8KDM4ETP53 | |
| SCHEMBL14349879 | 0.87 | HCAR2 (0.70) | HCAR2CYP2C9CYP2C8KDM4ETP53 | |
| SCHEMBL14349874 | 0.82 | HCAR2 (1.00) | HCAR2CYP2C9CYP2C8 | |
| SCHEMBL14349870 | 0.82 | HCAR2 (0.63) | HCAR2CYP2C9CYP2C8KDM4ETP53 | |
| SCHEMBL14349876 | 0.80 | HCAR2 (0.81) | HCAR2CYP2C9CYP2C8KDM4EKMT2A | |
| SCHEMBL14349878 | 0.80 | HCAR2 (0.52) | HCAR2CYP2C9KDM4ETP53ALDH1A1 | |
| SCHEMBL14349859 | 0.76 | HCAR2 (0.79) | HCAR2CYP2C9CYP2C8KDM4ETP53 | |
| SCHEMBL14349868 | 0.76 | HCAR2 (0.56) | HCAR2CYP2C9CYP2C8KDM4EKMT2A | |
| SCHEMBL14349860 | 0.75 | HCAR2 (0.57) | HCAR2CYP2C9CYP2C8KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299101-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | MERCK SHARP & DOHME CORP. | 2007-12-27 | — | — | US | disclosed |
| US-20070299101-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | MERCK SHARP & DOHME CORP. | 2007-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299101-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | LDLR, APOB, FFAR1 | HCAR2 20/4885CYP2C9 973/4885CYP2C8 1313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.