Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11754183 | 1.00 | TSHR (0.48) | TSHRALDH1A1AKR1C3USP2ALOX15 | |
| SCHEMBL1434 | 1.00 | TSHR (0.48) | TSHRALDH1A1AKR1C3USP2ALOX15 | |
| SCHEMBL5078610 | 0.79 | TSHR (0.50) | TSHRALDH1A1AKR1C3USP2ALOX15 | |
| SCHEMBL598599 | 0.79 | TSHR (0.50) | TSHRALDH1A1AKR1C3USP2ALOX15 | |
| SCHEMBL295402 | 0.79 | TSHR (0.50) | TSHRALDH1A1AKR1C3USP2ALOX15 | |
| SCHEMBL110774 | 0.79 | TSHR (0.50) | TSHRALDH1A1AKR1C3USP2ALOX15 | |
| SCHEMBL5027068 | 0.79 | TSHR (0.50) | TSHRALDH1A1AKR1C3USP2ALOX15 | |
| SCHEMBL295401 | 0.79 | TSHR (0.50) | TSHRALDH1A1AKR1C3USP2ALOX15 | |
| SCHEMBL3596805 | 0.77 | AKR1C3 (0.54) | TSHRALDH1A1AKR1C3USP2ALOX15 | |
| SCHEMBL3470164 | 0.77 | TSHR (0.54) | TSHRALDH1A1AKR1C3USP2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |
| EP-0435827-A2 | Diaza compounds | CIBA-GEIGY AG (CH) | 1991-07-03 | — | — | EP | disclosed |
| EP-0424317-A2 | Pyrimidines | CIBA-GEIGY AG (CH) | 1991-04-24 | — | — | EP | disclosed |
| EP-0415886-A2 | Aza compounds | CIBA-GEIGY AG (CH) | 1991-03-06 | — | — | EP | disclosed |
| EP-0407342-A2 | Pyrimidine derivatives | CIBA-GEIGY AG (CH) | 1991-01-09 | — | — | EP | disclosed |