SCHEMBL1435262

SCHEMBL1435262

CN1C(=S)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C1(C)C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 15/20 1.00
HDAC1 Q13547 2/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30291858 1.00 AR (1.00) ARHDAC1
SCHEMBL4031610 0.89 AR (0.80) ARHDAC1
SCHEMBL7035063 0.88 AR (0.87) ARHDAC1
SCHEMBL4026199 0.88 AR (0.78) AR
SCHEMBL8939558 0.87 AR (0.77) ARHDAC1
SCHEMBL4024954 0.86 AR (0.76) ARHDAC1
SCHEMBL4023040 0.86 AR (0.75) ARHDAC1
SCHEMBL4024956 0.85 AR (0.77) ARHDAC1
SCHEMBL8704637 0.85 AR (0.77) ARHDAC1
SCHEMBL4023027 0.85 AR (0.74) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE35956-E Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1998-11-10 US claimed
US-5627201-A Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1997-05-06 US claimed
EP-0494819-B1 Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 1996-07-10 EP claimed
US-5411981-A Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1995-05-02 US claimed
EP-0494819-A1 Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 1992-07-15 EP claimed
WO-2023275091-A1 PROCESSES FOR THE PREPARATION OF NON-STEROIDAL ANTIANDROGENS Química Sintética, S.A. (ES) 2023-01-05 WO disclosed
EP-4112603-A1 PROCESSES FOR THE PREPARATION OF NON-STEROIDAL ANTIANDROGENS Química Sintética, S.A. (ES) 2023-01-04 EP disclosed
EP-3725778-B1 FORMULATIONS OF ENZALUTAMIDE MEDIVATION PROSTATE THERAPEUTICS LLC (US) 2021-08-18 EP disclosed
US-20210040044-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR Arvinas, Inc. 2021-02-11 US disclosed
US-10844021-B2 Compounds and methods for the targeted degradation of androgen receptor ARVINAS OPERATIONS, INC. (US) 2020-11-24 US disclosed
EP-3660004-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR Arvinas Operations, Inc. (US) 2020-06-03 EP disclosed
WO-2020042622-A1 COMPOUND, COMPOSITION, AND USE THEREOF IN PREPARATION OF DRUG 长沙泽达医药科技有限公司 2020-03-05 WO disclosed
EP-0671156-B1 Process to prepare cosmetic or pharmaceutical compositions containing liposomes AVENTIS PHARMA SA (FR) 2001-10-24 EP disclosed
US-6162444-A Cosmetic or pharmaceutical compositions HOECHST MARION ROUSSEL (FR) 2000-12-19 US disclosed
US-RE35956-E Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1998-11-10 US disclosed
US-5627201-A Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1997-05-06 US disclosed
EP-0494819-B1 Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 1996-07-10 EP disclosed
EP-0671156-A1 Cosmetic or pharmaceutical compositions containing liposomes ROUSSEL UCLAF (FR) 1995-09-13 EP disclosed
US-5411981-A Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1995-05-02 US disclosed
EP-0494819-A1 Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 1992-07-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210040044-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR AR, ADRM1, CRBN AR 1/4885HDAC1 1306/4885
US-10844021-B2 Compounds and methods for the targeted degradation of androgen receptor AR, ADRM1, CRBN AR 1/4885HDAC1 1306/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.