Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 7/20 | 1.00 |
| ▸ | RAF1 | P04049 | 7/20 | 0.90 |
| ▸ | KDR | P35968 | 6/20 | 0.90 |
| ▸ | LCK | P06239 | 3/20 | 0.90 |
| ▸ | FYN | P06241 | 3/20 | 0.90 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.90 |
| ▸ | KIT | P10721 | 3/20 | 0.90 |
| ▸ | FLT1 | P17948 | 3/20 | 0.90 |
| ▸ | FLT4 | P35916 | 3/20 | 0.90 |
| ▸ | STK25 | O00506 | 1/20 | 0.90 |
| ▸ | CIT | O14578 | 1/20 | 0.90 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.90 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.90 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.90 |
| ▸ | PAK3 | O75914 | 1/20 | 0.90 |
| ▸ | STK10 | O94804 | 1/20 | 0.90 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.90 |
| ▸ | ABL1 | P00519 | 1/20 | 0.90 |
| ▸ | CSF1R | P07333 | 1/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19661215 | 0.95 | BRAF (0.91) | BRAFCYP3A4RAF1KDRLCK | |
| Raf-265 SCHEMBL29355586 | 0.95 | BRAF (1.00) | BRAFCYP3A4RAF1KDRLCK | |
| Raf-265 SCHEMBL686452 | 0.95 | BRAF (1.00) | BRAFCYP3A4RAF1KDRLCK | |
| Raf-265 SCHEMBL29368571 | 0.95 | BRAF (1.00) | BRAFCYP3A4RAF1KDRLCK | |
| Raf-265 SCHEMBL1562237 | 0.95 | BRAF (1.00) | BRAFCYP3A4RAF1KDRLCK | |
| SCHEMBL9976647 | 0.92 | BRAF (0.90) | BRAFCYP3A4RAF1KDRLCK | |
| SCHEMBL11996499 | 0.92 | BRAF (0.87) | BRAFCYP3A4RAF1KDRLCK | |
| SCHEMBL681128 | 0.92 | BRAF (0.87) | BRAFCYP3A4RAF1KDRLCK | |
| SCHEMBL4563102 | 0.91 | BRAF (0.86) | BRAFCYP3A4RAF1KDRLCK | |
| SCHEMBL1435392 | 0.91 | BRAF (1.00) | BRAFCYP3A4RAF1KDRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8592459-B2 | Substituted benzimidazoles and methods of their use | NOVARTIS AG (CH) | 2013-11-26 | — | — | US | claimed |
| EP-1926722-B1 | SUBSTITUTED BENZIMIDAZOLES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-09-28 | — | — | EP | claimed |
| EP-1924577-B1 | SUBSTITUTED BENZIMIDAZOLES AND METHODS OF PREPARATION | NOVARTIS AG (CH) | 2011-03-30 | — | — | EP | claimed |
| US-20100256375-A1 | SUBSTITUTED BENZIMIDAZOLES AND METHODS OF PREPARATION | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2010-10-07 | — | — | US | claimed |
| US-20100234394-A1 | SUBSTITUTED BENZIMIDAZOLES AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2010-09-16 | — | — | US | claimed |
| US-7763588-B2 | Method for increasing cognitive function and neurogenesis | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2010-07-27 | — | — | US | claimed |
| US-20080287682-A1 | Substituted benzimidazoles and methods of preparation | NOVARTIS AG | 2008-11-20 | — | — | US | claimed |
| EP-1926722-A1 | SUBSTITUTED BENZIMIDAZOLES AS KINASE INHIBITORS | Novartis AG (CH) | 2008-06-04 | — | — | EP | claimed |
| WO-2007030377-A1 | SUBSTITUTED BENZIMIDAZOLES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2007-03-15 | — | — | WO | claimed |
| US-20070049622-A1 | Substituted benzimidazoles and methods of preparation | NOVARTIS AG | 2007-03-01 | — | — | US | claimed |
| EP-2542097-B1 | PALATABLE BEVERAGES AND COMPOSITIONS WITH COCOA EXTRACT | MARS INC (US) | 2017-11-08 | — | — | EP | disclosed |
| US-8592459-B2 | Substituted benzimidazoles and methods of their use | NOVARTIS AG (CH) | 2013-11-26 | — | — | US | disclosed |
| US-20110301184-A1 | PHARMACEUTICAL COMBINATIONS COMPRISING A MTOR INHIBITOR AND A RAF KINASE INHIBITOR | NOVARTIS AG (CH) | 2011-12-08 | — | — | US | disclosed |
| EP-1926722-B1 | SUBSTITUTED BENZIMIDAZOLES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-09-28 | — | — | EP | disclosed |
| EP-1924577-B1 | SUBSTITUTED BENZIMIDAZOLES AND METHODS OF PREPARATION | NOVARTIS AG (CH) | 2011-03-30 | — | — | EP | disclosed |
| US-20070049622-A1 | Substituted benzimidazoles and methods of preparation | NOVARTIS AG | 2007-03-01 | — | — | US | disclosed |
| US-20070049622-A1 | Substituted benzimidazoles and methods of preparation | NOVARTIS AG | 2007-03-01 | — | — | US | disclosed |
| US-20070049622-A1 | Substituted benzimidazoles and methods of preparation | NOVARTIS AG | 2007-03-01 | — | — | US | disclosed |
| WO-2007002881-A2 | COMPOSITIONS AND METHODS OF USE OF DERIVATIZED FLAVANOLS | MARS, INCORPORATED (US) | 2007-01-04 | — | — | WO | disclosed |
| US-20060293259-A1 | Compositions and methods of use of derivatized flavanols | MARS, INCORPORATED (US) | 2006-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049622-A1 | Substituted benzimidazoles and methods of preparation | ABL1, CDK2, KIT | BRAF 29/4885CYP3A4 567/4885RAF1 73/4885 |
| US-20100256375-A1 | SUBSTITUTED BENZIMIDAZOLES AND METHODS OF PREPARATION | ABL1, CDK2, KIT | BRAF 29/4885CYP3A4 567/4885RAF1 73/4885 |
| US-20060293259-A1 | Compositions and methods of use of derivatized flavanols | F2, PIGS, PIGO | BRAF 2876/4885CYP3A4 865/4885RAF1 2498/4885 |
| US-20100234394-A1 | SUBSTITUTED BENZIMIDAZOLES AND METHODS OF THEIR USE | BRAF, DSTYK, CHEK2 | BRAF 1/4885CYP3A4 1957/4885RAF1 57/4885 |
| US-20110301184-A1 | PHARMACEUTICAL COMBINATIONS COMPRISING A MTOR INHIBITOR AND A RAF KINASE INHIBITOR | BRAF, RAF1, MTOR | BRAF 1/4885CYP3A4 2670/4885RAF1 2/4885 |
| US-20080287682-A1 | Substituted benzimidazoles and methods of preparation | ABL1, CDK2, KIT | BRAF 29/4885CYP3A4 567/4885RAF1 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.