Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4688475 | 0.87 | CAMK2D (0.41) | P2RY12CA12CA9LMNAPPARG | |
| SCHEMBL4688356 | 0.86 | P2RY12 (0.49) | P2RY12LMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL14357212 | 0.85 | P2RY12 (0.49) | P2RY12CA12CA9LMNAPPARG | |
| SCHEMBL14357209 | 0.84 | P2RY12 (0.55) | P2RY12CA12CA9LMNAPPARG | |
| SCHEMBL4689072 | 0.84 | P2RY12 (0.54) | P2RY12LMNAMEN1KMT2ATP53 | |
| SCHEMBL2947719 | 0.84 | P2RY12 (0.67) | P2RY12LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL14357267 | 0.84 | P2RY12 (0.45) | P2RY12CA12CA9LMNAPPARG | |
| SCHEMBL14357257 | 0.83 | P2RY12 (0.52) | P2RY12MEN1KMT2ATP53 | |
| SCHEMBL14357216 | 0.83 | P2RY12 (0.54) | P2RY12CA12CA9LMNAMEN1 | |
| SCHEMBL14357274 | 0.83 | P2RY12 (0.48) | P2RY12CA12CA9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294635-B2 | Substituted isoquinolinones | PORTOLA PHARMACEUTICALS, INC. (US) | 2007-11-13 | — | — | US | disclosed |
| US-7294635-B2 | Substituted isoquinolinones | PORTOLA PHARMACEUTICALS, INC. (US) | 2007-11-13 | — | — | US | disclosed |