Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.42 |
| ▸ | PDE4A | P27815 | 14/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14364381 | 0.87 | PDE4B (0.35) | PDE4BPDE4D | |
| SCHEMBL8353640 | 0.83 | LMNA (0.46) | — | |
| SCHEMBL5022733 | 0.82 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL5023418 | 0.81 | PDE4B (0.51) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL14184593 | 0.80 | PDE4B (0.47) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL5023357 | 0.78 | PDE4B (0.51) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL5022238 | 0.77 | PDE4B (0.69) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL5022869 | 0.77 | PDE4B (0.56) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8353862 | 0.76 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL5025155 | 0.76 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4CP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554262-B1 | NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLENMARK PHARMACEUTICALS LTD (IN) | 2007-12-05 | — | — | EP | disclosed |