Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14364618 | 0.87 | ALDH1A1 (0.60) | ALDH1A1HPGDNPSR1SMN1; SMN2RPS6KA5 | |
| SCHEMBL1902418 | 0.82 | ALDH1A1 (0.65) | ALDH1A1HPGDNPSR1SMN1; SMN2RPS6KA5 | |
| SCHEMBL1901797 | 0.82 | ALDH1A1 (0.68) | ALDH1A1HPGDNPSR1SMN1; SMN2RPS6KA5 | |
| SCHEMBL30612244 | 0.80 | SMN1; SMN2 (0.65) | ALDH1A1HPGDNPSR1SMN1; SMN2RPS6KA5 | |
| SCHEMBL26922233 | 0.80 | SMN1; SMN2 (0.65) | ALDH1A1HPGDNPSR1SMN1; SMN2RPS6KA5 | |
| SCHEMBL1901354 | 0.79 | SMN1; SMN2 (0.60) | ALDH1A1HPGDNPSR1SMN1; SMN2RPS6KA5 | |
| SCHEMBL28496270 | 0.76 | FGFR1 (0.46) | ALDH1A1HPGDNPSR1FGFR1FLT3 | |
| SCHEMBL30061285 | 0.76 | FGFR1 (0.46) | ALDH1A1HPGDNPSR1FGFR1FLT3 | |
| SCHEMBL14364577 | 0.76 | HPGD (0.60) | ALDH1A1HPGDNPSR1SMN1; SMN2RPS6KA5 | |
| SCHEMBL1160565 | 0.76 | ALDH1A1 (1.00) | ALDH1A1HPGDNPSR1SMN1; SMN2RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322521-B1 | Heteroaryl compounds useful as inhibitors of GSK-3 | VERTEX PHARMA (US) | 2013-09-04 | — | — | EP | disclosed |
| US-20070270420-A1 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF GSK-3 | VERTEX PHARMACEUTICALS INCORPORATED | 2007-11-22 | — | — | US | disclosed |
| US-20070270420-A1 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF GSK-3 | VERTEX PHARMACEUTICALS INCORPORATED | 2007-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270420-A1 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF GSK-3 | GSK3B, GSK3A, GSKIP | ALDH1A1 3514/4885HPGD 2444/4885NPSR1 4422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.