Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033314 | 0.87 | PDE4D (0.59) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL4032324 | 0.85 | PDE4D (0.69) | PDE4DSMN1; SMN2RAB9AKMT2AMEN1 | |
| SCHEMBL4755347 | 0.85 | PDE4D (0.69) | PDE4DSMN1; SMN2RAB9AKMT2AMEN1 | |
| SCHEMBL13632194 | 0.84 | PDE4D (0.51) | PDE4DJAK2PDE4APDE4BPDE4C | |
| SCHEMBL6526531 | 0.82 | PDE4D (0.55) | PDE4DSMN1; SMN2CYP3A4MAPK1PDE4A | |
| SCHEMBL13794644 | 0.79 | PDE4D (0.74) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL13631994 | 0.78 | PDE4D (0.46) | PDE4DJAK2PDE4APDE4BPDE4C | |
| SCHEMBL13631920 | 0.78 | PDE4D (0.48) | PDE4DJAK2MAOAPDE4APDE4B | |
| SCHEMBL13777339 | 0.77 | PDE4D (0.55) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL14457761 | 0.75 | PDE4D (0.57) | PDE4DSMN1; SMN2RAB9AKMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554262-B1 | NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLENMARK PHARMACEUTICALS LTD (IN) | 2007-12-05 | — | — | EP | disclosed |