Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 9/20 | 0.45 |
| ▸ | AXL | P30530 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | INSR | P06213 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | ROS1 | P08922 | 2/20 | 0.44 |
| ▸ | FER | P16591 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | MARK3 | P27448 | 2/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.44 |
| ▸ | CLK2 | P49760 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857204 | 0.81 | CDK8 (0.61) | RIPK1CDK8AXLPLK4ROCK2 | |
| SCHEMBL14365332 | 0.81 | CDK8 (0.47) | RIPK1MAP4K1CDK8AXLPLK4 | |
| SCHEMBL14365341 | 0.80 | PIK3CD (0.47) | RIPK1MAP4K1CDK8AXLPLK4 | |
| SCHEMBL14365364 | 0.77 | BRD4 (0.48) | RIPK1MAP4K1CDK8AXLPLK4 | |
| SCHEMBL14365352 | 0.76 | CDK8 (0.47) | RIPK1MAP4K1CDK8AXLPLK4 | |
| SCHEMBL14365335 | 0.76 | PIK3CD (0.46) | RIPK1MAP4K1CDK8AXLPLK4 | |
| SCHEMBL14365342 | 0.74 | AXL (0.51) | RIPK1MAP4K1CDK8AXLPLK4 | |
| SCHEMBL14365339 | 0.73 | MAP4K1 (0.63) | RIPK1MAP4K1CDK8AXLPLK4 | |
| SCHEMBL12763450 | 0.73 | MAP3K11 (0.78) | CDK8ROCK2INSRCDK1CDK2 | |
| SCHEMBL3348289 | 0.72 | RIPK1 (0.65) | RIPK1MAP4K1CDK8AXLPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7291630-B2 | Azaindoles as inhibitors of c-Jun N-terminal kinases | EISAI CO., LTD. (JP) | 2007-11-06 | — | — | US | disclosed |
| US-7291630-B2 | Azaindoles as inhibitors of c-Jun N-terminal kinases | EISAI CO., LTD. (JP) | 2007-11-06 | — | — | US | disclosed |