Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | CA2 | P00918 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16079979 | 0.91 | CTNNB1 (0.49) | MAPTATMCTNNB1WNT3ACA1 | |
| SCHEMBL14679384 | 0.87 | NPC1 (0.54) | MAPTATMTDP1POLBHDAC3 | |
| SCHEMBL10322699 | 0.85 | L3MBTL1 (0.53) | MAPTTDP1CYP3A4CA1CA2 | |
| SCHEMBL17410238 | 0.85 | CA1 (0.48) | TDP1CYP3A4CA1CA2BRD4 | |
| SCHEMBL14679385 | 0.85 | NPC1 (0.54) | MAPTATMPOLBHDAC3HDAC1 | |
| SCHEMBL24365180 | 0.84 | HDAC3 (0.47) | MAPTTDP1CYP3A4CA1CA2 | |
| SCHEMBL29477839 | 0.84 | HDAC3 (0.47) | MAPTTDP1CYP3A4CA1CA2 | |
| SCHEMBL21509871 | 0.83 | CTNNB1 (0.45) | MAPTATMCTNNB1WNT3APOLB | |
| SCHEMBL2241024 | 0.82 | CA1 (0.48) | MAPTTDP1CYP3A4CTNNB1WNT3A | |
| SCHEMBL14679371 | 0.82 | NPC1 (0.57) | ATMPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |