Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30232786 | 0.87 | NOTUM (0.63) | HDAC1HDAC6NOTUMROCK2ROCK1 | |
| SCHEMBL1572534 | 0.87 | NOTUM (0.63) | HDAC1HDAC6NOTUMROCK2ROCK1 | |
| SCHEMBL1689982 | 0.85 | HDAC1 (0.48) | HDAC1HDAC6NOTUMROCK2ROCK1 | |
| SCHEMBL655024 | 0.83 | NOTUM (0.80) | HDAC1HDAC6NOTUMROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL2257588 | 0.82 | NOTUM (0.78) | HDAC1HDAC6NOTUMROCK2ROCK1 | |
| SCHEMBL5578837 | 0.82 | NOTUM (0.50) | HDAC1HDAC6NOTUMROCK2ROCK1 | |
| SCHEMBL10253494 | 0.81 | NOTUM (0.44) | HDAC1HDAC6NOTUMROCK2ROCK1 | |
| SCHEMBL5599645 | 0.80 | NOTUM (0.51) | HDAC1HDAC6NOTUMROCK2ROCK1 | |
| SCHEMBL6544407 | 0.80 | NOTUM (0.57) | HDAC1HDAC6NOTUMROCK2ROCK1 | |
| SCHEMBL6543796 | 0.80 | NOTUM (0.54) | HDAC1HDAC6NOTUMROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070254903-A1 | Novel Spiroindoline or Spiroisoquinoline Compounds, Methods of Use and Compositions Thereof | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-01 | — | — | US | disclosed |
| US-20070254903-A1 | Novel Spiroindoline or Spiroisoquinoline Compounds, Methods of Use and Compositions Thereof | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-01 | — | — | US | disclosed |
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254903-A1 | Novel Spiroindoline or Spiroisoquinoline Compounds, Methods of Use and Compositions Thereof | REN, AVPR2, RECQL | HDAC1 885/4885HDAC6 767/4885NOTUM 3318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.