Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 11/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 11/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 11/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 11/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 11/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 11/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4106052 | 1.00 | SMYD3 (0.48) | SMYD3KDM4EALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL3088596 | 1.00 | SMYD3 (0.48) | SMYD3KDM4EALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL5966991 | 0.94 | PSEN1 (0.47) | SMYD3KDM4EALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL3343185 | 0.85 | SMYD3 (0.50) | SMYD3KDM4EALDH1A1HTTPSEN1 | |
| SCHEMBL4111216 | 0.84 | TSHR (0.50) | SMYD3HTTPSEN1PSEN2APH1B | |
| SCHEMBL3343337 | 0.84 | TSHR (0.50) | SMYD3HTTPSEN1PSEN2APH1B | |
| SCHEMBL3343088 | 0.84 | THRA (0.52) | SMYD3KDM4EALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL5967316 | 0.83 | PSEN1 (0.47) | SMYD3KDM4EALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL5967298 | 0.83 | PSEN1 (0.52) | SMYD3PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2819918 | 0.83 | PSEN1 (0.51) | SMYD3ALDH1A1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294622-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2007-11-13 | — | — | US | disclosed |
| US-7294622-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2007-11-13 | — | — | US | disclosed |