Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340919 | 1.00 | TSHR (0.37) | TSHRKMT2AALDH1A1ATMRIPK1 | |
| SCHEMBL14260865 | 0.82 | TSHR (0.37) | TSHRKMT2AALDH1A1ATMHTR1A | |
| SCHEMBL8342144 | 0.82 | TSHR (0.37) | TSHRKMT2AALDH1A1ATMHTR1A | |
| Hydrochloric Acid SCHEMBL6208335 | 0.81 | TSHR (0.36) | TSHRKMT2AALDH1A1ATMHTR1A | |
| Hydrochloric Acid SCHEMBL3346789 | 0.81 | TSHR (0.36) | TSHRKMT2AALDH1A1ATMHTR1A | |
| SCHEMBL14260863 | 0.75 | ALDH1A1 (0.33) | TSHRKMT2AALDH1A1ATMHTR1A | |
| SCHEMBL14260864 | 0.72 | ALDH1A1 (0.33) | TSHRKMT2AALDH1A1ATMRIPK1 | |
| SCHEMBL14367235 | 0.72 | ALDH1A1 (0.33) | TSHRKMT2AALDH1A1ATMRIPK1 | |
| SCHEMBL3346896 | 0.72 | HSD17B10 (0.50) | TSHRKMT2AALDH1A1ADRA1AHTR2B | |
| SCHEMBL3343313 | 0.72 | HSD17B10 (0.50) | TSHRKMT2AALDH1A1ADRA1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294622-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2007-11-13 | — | — | US | disclosed |
| US-7294622-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2007-11-13 | — | — | US | disclosed |