Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | PREP | P48147 | 10/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594527 | 1.00 | HRH3 (0.46) | HRH3PREPDPP4KDM4EMEN1 | |
| SCHEMBL6327411 | 0.99 | HRH3 (0.45) | HRH3PREPDPP4KDM4EMEN1 | |
| SCHEMBL4594300 | 0.99 | HRH3 (0.45) | HRH3PREPDPP4KDM4EMEN1 | |
| SCHEMBL6828219 | 0.98 | PREP (0.47) | HRH3PREPDPP4KDM4EMEN1 | |
| SCHEMBL4593328 | 0.98 | PREP (0.47) | HRH3PREPDPP4KDM4EMEN1 | |
| SCHEMBL4593878 | 0.88 | GAA (0.49) | MEN1NPC1KMT2A | |
| SCHEMBL4593877 | 0.88 | GAA (0.49) | MEN1NPC1KMT2A | |
| SCHEMBL4594324 | 0.86 | ALDH1A1 (0.47) | PREPKDM4EMEN1KMT2A | |
| SCHEMBL4594321 | 0.86 | ALDH1A1 (0.47) | PREPKDM4EMEN1KMT2A | |
| SCHEMBL4594391 | 0.85 | PREP (0.40) | PREPDPP4KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441719-B1 | N-SUBSTITUTED PYRROLIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-03-30 | — | — | EP | disclosed |
| US-6861440-B2 | DPP IV inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2005-03-01 | — | — | US | disclosed |
| US-20030130281-A1 | DPP IV inhibitors | HOFFMAN-LA ROCHE INC. | 2003-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130281-A1 | DPP IV inhibitors | DPP4, DPP3, DPP7 | HRH3 3108/4885PREP 173/4885DPP4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.