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SCHEMBL14367406

SCHEMBL14367406

Cc1ccc(C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1S(=O)(=O)N1CCOCC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ CNR2 P34972 8/20 1.00
▸ CNR1 P21554 7/20 1.00
▸ RAB9A P51151 2/20 0.61
▸ MEN1 O00255 1/20 0.61
▸ KMT2A Q03164 1/20 0.61
▸ MAPT P10636 3/20 0.60
▸ ALDH1A1 P00352 1/20 0.60
▸ NPC1 O15118 3/20 0.59
▸ LMNA P02545 1/20 0.56
▸ TP53 P04637 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5794352 0.90 CNR2 (0.82) CNR2CNR1RAB9AMEN1KMT2A
SCHEMBL5623834 0.87 CNR2 (0.78) CNR2CNR1RAB9AMEN1KMT2A
SCHEMBL5623000 0.82 CNR2 (1.00) CNR2CNR1RAB9AMAPTNPC1
SCHEMBL5626636 0.81 CNR2 (1.00) CNR2CNR1RAB9AMAPTNPC1
SCHEMBL5623445 0.80 CNR2 (1.00) CNR2CNR1RAB9AMEN1KMT2A
SCHEMBL5794343 0.79 CNR1 (0.65) CNR2CNR1RAB9AMEN1KMT2A
SCHEMBL29717171 0.79 CNR2 (0.73) CNR2CNR1RAB9AMEN1KMT2A
SCHEMBL5623950 0.77 CNR2 (0.74) CNR2CNR1RAB9ANPC1
SCHEMBL5627497 0.77 CNR2 (0.74) CNR2CNR1RAB9ANPC1
SCHEMBL5793881 0.77 CNR2 (0.79) CNR2CNR1RAB9AMAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7297796-B2 Sulfamoyl benzamide derivatives and methods of their use ADOLOR CORPORATION (US) 2007-11-20 — — US disclosed