SCHEMBL14368453

SCHEMBL14368453

CC(C)N1CCCN(C(=O)c2ccc(NC(=O)N3CCn4c(c(C(N)=O)c(Cl)c4-c4ccccc4)C3)cc2)CC1

nearest known ligand 0.45

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ CSNK1E P49674 14/20 0.45
▸ CHRNA7 P36544 1/20 0.45
▸ NAMPT P43490 1/20 0.42
▸ CNR1 P21554 1/20 0.42
▸ CNR2 P34972 1/20 0.42
▸ EPHX2 P34913 1/20 0.41
▸ HRH3 Q9Y5N1 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14368452 0.97 CSNK1E (0.47) CSNK1ECHRNA7NAMPTEPHX2
SCHEMBL14368383 0.90 NAMPT (0.46) CSNK1ENAMPTCNR1CNR2
SCHEMBL13964269 0.88 NAMPT (0.49) CSNK1ENAMPT
SCHEMBL13963964 0.85 CSNK1E (0.49) CSNK1ENAMPT
SCHEMBL14368398 0.84 CSNK1E (0.52) CSNK1E
SCHEMBL13964334 0.84 CSNK1E (0.50) CSNK1ENAMPT
SCHEMBL4041559 0.84 CSNK1E (0.49) CSNK1E
SCHEMBL14368388 0.83 CSNK1E (0.53) CSNK1E
SCHEMBL13963918 0.82 CSNK1E (0.52) CSNK1ENAMPT
SCHEMBL14368412 0.82 CSNK1E (0.51) CSNK1E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070238734-A1 JNK INHIBITORS SANOLI-AVENTIS (FR) 2007-10-11 — — US disclosed
US-20070238734-A1 JNK INHIBITORS SANOLI-AVENTIS (FR) 2007-10-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070238734-A1 JNK INHIBITORS MAP3K7, MAPKAPK2, MAPK7 CSNK1E 136/4885CHRNA7 4538/4885NAMPT 2464/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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