Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 13/20 | 0.48 |
| ▸ | CASP7 | P55210 | 10/20 | 0.47 |
| ▸ | CASP1 | P29466 | 6/20 | 0.46 |
| ▸ | CASP9 | P55211 | 5/20 | 0.46 |
| ▸ | CASP4 | P49662 | 2/20 | 0.45 |
| ▸ | CASP10 | Q92851 | 2/20 | 0.44 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.44 |
| ▸ | PRSS8 | Q16651 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL950389 | 1.00 | ELANE (0.51) | ELANECASP3CASP7CASP1CASP9 | |
| SCHEMBL952481 | 1.00 | ELANE (0.51) | ELANECASP3CASP7CASP1CASP9 | |
| SCHEMBL4460244 | 0.90 | ELANE (0.51) | ELANECASP3CASP1PRSS8 | |
| SCHEMBL12946542 | 0.83 | CASP3 (0.50) | ELANECASP3CASP7CASP1CASP9 | |
| SCHEMBL12946453 | 0.83 | CASP3 (0.48) | ELANECASP3CASP7CASP1CASP9 | |
| SCHEMBL12946467 | 0.83 | CASP3 (0.48) | ELANECASP3CASP7CASP1CASP9 | |
| SCHEMBL14370015 | 0.83 | CASP3 (0.43) | ELANECASP3 | |
| SCHEMBL2801278 | 0.82 | CASP3 (0.47) | ELANECASP3CASP7CASP1 | |
| SCHEMBL614741 | 0.81 | CASP3 (0.62) | ELANECASP3CASP7CASP1CASP9 | |
| SCHEMBL3140616 | 0.81 | CASP3 (0.62) | ELANECASP3CASP7CASP1CASP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288624-B2 | Inhibitors of interleukin-1β converting enzyme | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-30 | — | — | US | disclosed |
| US-7288624-B2 | Inhibitors of interleukin-1β converting enzyme | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-30 | — | — | US | disclosed |