Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14347303 | 0.79 | CDC7 (0.36) | DYRK1AAURKADAPK3JAK2ROCK2 | |
| SCHEMBL14374170 | 0.73 | MAPT (0.56) | PDE3BPDE3A | |
| SCHEMBL14374178 | 0.72 | KDM4E (0.42) | PDE3BPDE3A | |
| SCHEMBL14374967 | 0.72 | CYP1A2 (0.35) | DYRK1AAURKADAPK3JAK2ROCK2 | |
| SCHEMBL14374646 | 0.71 | HTR2C (0.39) | DYRK1AAURKADAPK3JAK2ROCK2 | |
| SCHEMBL14374978 | 0.69 | TSHR (0.51) | MAPK1HPGDPARP1 | |
| SCHEMBL23169453 | 0.69 | PDE3B (0.42) | DYRK1APDE3BPDE3AKDM4CHTR6 | |
| SCHEMBL14374778 | 0.68 | RXFP1 (0.43) | DYRK1ACDK1CDK5PLK3HPGD | |
| SCHEMBL14347262 | 0.68 | CDC7 (0.48) | DYRK1AAURKADAPK3JAK2ROCK2 | |
| SCHEMBL18237557 | 0.66 | PDE3B (0.44) | PDE3BPDE3AHPGDGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312211-B2 | Pryanone compounds useful as reversible inhibitors of cysteine proteases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2007-12-25 | — | — | US | disclosed |