Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | GRK2 | P25098 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | WDR5 | P61964 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852806 | 0.90 | GSK3B (0.57) | GSK3BROCK2GRK2SMN1; SMN2MAPK1 | |
| Trifluoroacetic Acid SCHEMBL5658055 | 0.84 | GSK3B (0.54) | GSK3BROCK2GRK2SMN1; SMN2MAPK1 | |
| SCHEMBL4855778 | 0.80 | GSK3B (0.62) | GSK3BROCK2SMN1; SMN2MAPK1GAA | |
| SCHEMBL4848821 | 0.78 | GSK3B (0.65) | GSK3BROCK2MAPK1GAAHPGD | |
| SCHEMBL4848500 | 0.77 | GSK3B (0.62) | GSK3BROCK2GRK2SMN1; SMN2MAPK1 | |
| SCHEMBL5226253 | 0.75 | GSK3B (0.60) | GSK3BROCK2GRK2SMN1; SMN2MAPK1 | |
| SCHEMBL4856282 | 0.75 | GSK3B (0.69) | GSK3BROCK2GRK2SMN1; SMN2MAPK1 | |
| SCHEMBL4856466 | 0.73 | GSK3B (0.64) | GSK3BROCK2GRK2SMN1; SMN2MAPK1 | |
| SCHEMBL4856280 | 0.72 | GSK3B (0.75) | GSK3BROCK2GRK2MAPK1GAA | |
| SCHEMBL4848952 | 0.72 | GSK3B (0.62) | GSK3BROCK2GRK2SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |