Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | WDR5 | P61964 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | GRK2 | P25098 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852806 | 0.94 | GSK3B (0.57) | GSK3BWDR5ROCK2GRK2HPGD | |
| SCHEMBL14374765 | 0.84 | GSK3B (0.46) | GSK3BWDR5ROCK2GRK2HPGD | |
| SCHEMBL4848821 | 0.84 | GSK3B (0.65) | GSK3BWDR5ROCK2HPGDMAPK1 | |
| SCHEMBL4855778 | 0.84 | GSK3B (0.62) | GSK3BROCK2HPGDMAPK1MAPT | |
| Trifluoroacetic Acid SCHEMBL5657525 | 0.81 | GSK3B (0.61) | GSK3BWDR5MAPK1MAPTLMNA | |
| Trifluoroacetic Acid SCHEMBL5657353 | 0.80 | GSK3B (0.58) | GSK3BROCK2GRK2HPGDMAPK1 | |
| Trifluoroacetic Acid SCHEMBL5656836 | 0.78 | GSK3B (0.56) | GSK3BROCK2GRK2HPGDMAPK1 | |
| Trifluoroacetic Acid SCHEMBL5659124 | 0.78 | GSK3B (0.61) | GSK3BROCK2MAPK1MAPTSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5659047 | 0.78 | GSK3B (0.58) | GSK3BMAPTSMN1; SMN2CYP2C9NPSR1 | |
| SCHEMBL4856682 | 0.78 | GSK3B (0.69) | GSK3BROCK2GRK2HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |