Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KCNJ6 | P48051 | 10/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 10/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 5/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | MAT2A | P31153 | 1/20 | 0.36 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14401146 | 0.81 | JAK2 (0.43) | GAACYP3A4CYP2C19KCNJ6KCNJ3 | |
| SCHEMBL17580256 | 0.81 | KDM4E (0.36) | KDM4EKMT2AGAACYP3A4CYP2C19 | |
| SCHEMBL25793174 | 0.73 | KCNJ6 (0.69) | KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL24007919 | 0.73 | TMIGD3 (0.43) | KDM4EKMT2AGAACYP3A4CYP2C19 | |
| SCHEMBL19091627 | 0.73 | KDM4E (0.40) | KDM4EKMT2ARETMAT2APSMD14 | |
| SCHEMBL17580560 | 0.72 | MAP3K14 (0.41) | RET | |
| SCHEMBL18055557 | 0.71 | KDM4E (0.38) | KDM4EKMT2ARET | |
| SCHEMBL6887721 | 0.71 | MAP3K12 (0.40) | KDM4EKMT2ARET | |
| SCHEMBL19650841 | 0.70 | KDM4E (0.39) | KDM4EKMT2ARETMAT2A | |
| SCHEMBL21178704 | 0.69 | KDM4E (0.38) | KDM4EKMT2ARET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279474-B2 | Substituted pyrrolo[2,3-d]pyrimidines as antagonists of the corticotropin releasing factor (CRF) | GLAXO GROUP LIMITED (GB) | 2007-10-09 | — | — | US | disclosed |