Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.35 |
| ▸ | RET | P07949 | 6/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KCNJ6 | P48051 | 4/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17580560 | 0.90 | MAP3K14 (0.41) | ALKRETMAP3K14 | |
| SCHEMBL14375500 | 0.81 | KDM4E (0.40) | KDM4EKMT2ARETCYP3A4GAA | |
| SCHEMBL19650841 | 0.78 | KDM4E (0.39) | KDM4EKMT2ARET | |
| SCHEMBL17580428 | 0.76 | KCNJ6 (0.40) | GAAKCNJ6KCNJ3KCNJ5 | |
| SCHEMBL13923328 | 0.76 | MAPK13 (0.33) | KDM4EGAAKCNJ6KCNJ3KCNJ5 | |
| SCHEMBL19091627 | 0.74 | KDM4E (0.40) | KDM4EKMT2ARETOPRM1OPRD1 | |
| SCHEMBL18055557 | 0.72 | KDM4E (0.38) | KDM4EKMT2ARET | |
| SCHEMBL6887721 | 0.72 | MAP3K12 (0.40) | KDM4EKMT2ARET | |
| SCHEMBL17580180 | 0.71 | KCNJ6 (0.55) | KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL21178704 | 0.70 | KDM4E (0.38) | KDM4EKMT2ARET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834248-B1 | NOVEL THIENOPYRIMIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI SA (FR) | 2016-03-16 | — | — | EP | disclosed |