Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.67 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | TLK2 | Q86UE8 | 6/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CDK7 | P50613 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14376567 | 0.86 | TLK2 (0.66) | RETTLK2LRRK2CDK2PDPK1 | |
| SCHEMBL14375844 | 0.84 | TLK2 (0.52) | RETTLK2LRRK2CDK2PDPK1 | |
| SCHEMBL14375876 | 0.83 | RET (0.65) | RETCES1TLK2LRRK2CDK2 | |
| SCHEMBL15896535 | 0.83 | LRRK2 (0.70) | RETTLK2LRRK2CDK2PDPK1 | |
| SCHEMBL14375852 | 0.83 | LRRK2 (0.72) | RETCES1TLK2LRRK2CDK2 | |
| SCHEMBL15878789 | 0.83 | LRRK2 (0.72) | RETCES1TLK2LRRK2CDK2 | |
| SCHEMBL14376387 | 0.82 | MEN1 (0.57) | RETTLK2CDK2PDPK1KDR | |
| SCHEMBL14375845 | 0.79 | RET (0.62) | RETLRRK2PDGFRBRPS6KA3TGM2 | |
| SCHEMBL14376375 | 0.79 | RET (0.59) | RETCES1TLK2LRRK2CDK2 | |
| SCHEMBL14376577 | 0.78 | NPC1 (0.63) | RETCES1TLK2LRRK2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140205537-A1 | LRRK2 INHIBITORS | ZENOBIA THERAPEUTICS, INC. (US) | 2014-07-24 | — | — | US | disclosed |
| WO-2012178015-A2 | LRRK2 INHIBITORS | ZENOBIA THERAPEUTICS, INC. (US) | 2012-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140205537-A1 | LRRK2 INHIBITORS | LRRK2, PARK7, MAP2 | RET 789/4885CES1 4336/4885TLK2 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.