Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 20/20 | 0.65 |
| ▸ | KIT | P10721 | 16/20 | 0.65 |
| ▸ | BCR | P11274 | 9/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.65 |
| ▸ | RAD52 | P43351 | 1/20 | 0.65 |
| ▸ | ABL2 | P42684 | 11/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | DDX3X | O00571 | 1/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.62 |
| ▸ | CA12 | O43570 | 1/20 | 0.62 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | ALB | P02768 | 1/20 | 0.62 |
| ▸ | RAF1 | P04049 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14375919 | 0.91 | ABL1 (0.54) | ABL1KITBCRPDGFRARAD52 | |
| SCHEMBL14375883 | 0.88 | ABL1 (0.73) | ABL1KITBCRPDGFRARAD52 | |
| SCHEMBL14375879 | 0.87 | ABL1 (0.87) | ABL1KITBCRPDGFRARAD52 | |
| SCHEMBL14375886 | 0.86 | ABL1 (0.60) | ABL1KITBCRPDGFRARAD52 | |
| SCHEMBL14375804 | 0.84 | ALDH1A1 (0.64) | ABL1KITBCRPDGFRARAD52 | |
| SCHEMBL14375954 | 0.80 | ALDH1A1 (0.51) | ABL1KITBCRPDGFRARAD52 | |
| SCHEMBL3988406 | 0.79 | ABL1 (0.78) | ABL1KITBCRPDGFRARAD52 | |
| Imatinib SCHEMBL15632914 | 0.79 | ABL1 (1.00) | ABL1KITBCRPDGFRARAD52 | |
| SCHEMBL13314477 | 0.79 | ABL1 (0.86) | ABL1KITBCRPDGFRARAD52 | |
| Imatinib SCHEMBL5004429 | 0.79 | ABL1 (0.97) | ABL1KITBCRPDGFRARAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279576-B2 | Anti-cancer medicaments | DECIPHERA PHARMACEUTICALS, LLC (US) | 2007-10-09 | — | — | US | disclosed |
| US-7279576-B2 | Anti-cancer medicaments | DECIPHERA PHARMACEUTICALS, LLC (US) | 2007-10-09 | — | — | US | disclosed |