Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14241707 | 0.83 | LMNA (0.47) | LMNASMN1; SMN2JAK2PDE4BALDH1A1 | |
| SCHEMBL14241412 | 0.83 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2JAK2PDE4BALDH1A1 | |
| SCHEMBL14349672 | 0.80 | LMNA (0.45) | LMNASMN1; SMN2JAK2PDE4BUSP30 | |
| SCHEMBL27302585 | 0.79 | JAK2 (0.48) | LMNASMN1; SMN2JAK2USP30JAK1 | |
| SCHEMBL6887260 | 0.79 | USP30 (0.57) | LMNASMN1; SMN2ALDH1A1USP30JAK1 | |
| SCHEMBL18694469 | 0.79 | LMNA (0.50) | LMNASMN1; SMN2JAK2PDE4BALDH1A1 | |
| SCHEMBL27302588 | 0.79 | LMNA (0.44) | LMNASMN1; SMN2JAK2PDE4BALDH1A1 | |
| SCHEMBL19145770 | 0.78 | MAPK1 (0.53) | LMNASMN1; SMN2MAPK1PDE4BALDH1A1 | |
| SCHEMBL14376065 | 0.78 | LMNA (0.44) | LMNASMN1; SMN2JAK2PDE4BALDH1A1 | |
| SCHEMBL14241708 | 0.77 | JAK2 (0.49) | LMNASMN1; SMN2JAK2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312209-B2 | Acridone inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-25 | — | — | US | disclosed |