Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.47 |
| ▸ | GAK | O14976 | 3/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | KHK | P50053 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14375972 | 0.81 | ALDH1A1 (0.54) | LRRK2RXFP1ALDH1A1HPGDKHK | |
| SCHEMBL14376035 | 0.80 | PDE10A (0.52) | PDE10ALRRK2GAKTRPM8ALDH1A1 | |
| SCHEMBL15652664 | 0.78 | PDE10A (0.51) | PDE10ALRRK2GAKTRPM8KDM4E | |
| SCHEMBL13678372 | 0.78 | PDE10A (0.51) | PDE10ALRRK2GAKTRPM8ALDH1A1 | |
| SCHEMBL13271359 | 0.78 | PDE10A (0.51) | PDE10ALRRK2GAKTRPM8ALDH1A1 | |
| SCHEMBL17478867 | 0.78 | ALDH1A1 (0.60) | LRRK2ALDH1A1KDM4E | |
| SCHEMBL25239858 | 0.76 | ALDH1A1 (0.51) | PDE10AGAKTRPM8ALDH1A1GAA | |
| SCHEMBL14349675 | 0.76 | PDE10A (0.49) | PDE10ALRRK2GAKTRPM8ALDH1A1 | |
| SCHEMBL30454819 | 0.76 | ALDH1A1 (0.51) | PDE10AGAKTRPM8ALDH1A1GAA | |
| SCHEMBL3948357 | 0.75 | KDM4E (0.57) | LRRK2RXFP1ALDH1A1HPGDKHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312209-B2 | Acridone inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-25 | — | — | US | disclosed |