Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 12/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 12/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9894116 | 0.86 | GABRA2 (0.46) | GABRA2GABRB2MDM2 | |
| SCHEMBL1437358 | 0.85 | MDM2 (0.41) | MDM2PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1437375 | 0.81 | MDM2 (0.45) | GABRA2GABRB2MDM2KLKB1 | |
| SCHEMBL1438066 | 0.81 | MDM2 (0.57) | MDM2PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1437715 | 0.77 | MDM2 (0.37) | GABRA2GABRB2MDM2PDE4BPDE4D | |
| SCHEMBL1437544 | 0.77 | KDM4E (0.32) | MDM2KDM4EALDH1A1TSHRTDP1 | |
| SCHEMBL1437021 | 0.74 | MDM2 (0.68) | MDM2 | |
| SCHEMBL1437275 | 0.74 | MDM2 (0.67) | MDM2 | |
| SCHEMBL9894095 | 0.72 | MDM2 (0.46) | GABRA2GABRB2MDM2 | |
| SCHEMBL14692500 | 0.72 | GABRA2 (0.51) | GABRA2GABRB2PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470502-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | Novartis AG (CH) | 2012-07-04 | — | — | EP | disclosed |
| WO-2011023677-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | NOVARTIS AG (CH) | 2011-03-03 | — | — | WO | disclosed |