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GABRA2

Gamma-aminobutyric acid receptor subunit alpha-2 · P47869 · GABRA2 on Sugi Atlas →

186,097 patent compounds predicted against GABRA2, 95,625 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL15406 SCHEMBL15406 0.61 20/20
Fipronil Fipronil (SCHEMBL15088) 0.59 20/20
SCHEMBL41972 SCHEMBL41972 0.59 20/20
Fipronil Fipronil (SCHEMBL44222) 0.59 20/20
Ethiprole Ethiprole (SCHEMBL27048) 0.56 20/20
SCHEMBL26584 SCHEMBL26584 0.51 20/20
SCHEMBL25897 SCHEMBL25897 0.51 20/20
SCHEMBL33214 SCHEMBL33214 0.52 19/20
Flumazenil Flumazenil (SCHEMBL79030) 1.00 14/20
Iomazenil Iomazenil (SCHEMBL41658) 0.71 12/20
SCHEMBL9107 SCHEMBL9107 0.56 12/20
SCHEMBL8532 SCHEMBL8532 1.00 11/20
SCHEMBL9035 SCHEMBL9035 0.56 10/20
SCHEMBL8632 SCHEMBL8632 0.54 10/20
Flunitrazepam Flunitrazepam (SCHEMBL44169) 1.00 9/20
Ro-54864 Ro-54864 (SCHEMBL60200) 0.85 9/20
SCHEMBL8670 SCHEMBL8670 0.57 9/20
SCHEMBL8856 SCHEMBL8856 0.53 9/20
SCHEMBL9273 SCHEMBL9273 0.53 9/20
SCHEMBL8931 SCHEMBL8931 0.51 9/20

Clinical trials — most relevant to GABRA2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Computational Assessment of GABA Receptor Modulation in PTSD PHASE4RECRUITING
Safety of Ramelteon in Elderly Subjects PHASE4COMPLETED
Attenuate the Stress Response in Laparoscopic Cholecystectomy PHASE4NOT_YET_RECRUITING
Bispectral Index-guided Sedation for Flexible Bronchoscopy PHASE4COMPLETED
The Effects of Levetiracetam on Alcohol Dependent Subjects PHASE4COMPLETED
Evaluating the Safety of Acute Baclofen in Methadone-maintained Individuals With Opiate Dependence. PHASE4COMPLETED
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia PHASE3COMPLETED
Safety and Efficacy of Ramelteon and Doxepin in Subjects With Chronic Insomnia PHASE2COMPLETED
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia PHASE2COMPLETED
Diazepam Trial in GAD65 Associated Epilepsy PHASE1/PHASE2WITHDRAWN
MENDS Study: Trial in Ventilated ICU Patients Comparing an Alpha2 Agonist Versus a Gamma Aminobutyric Acid (GABA)-Agonist to Determine Delirium Rates, Efficacy of Sedation, Analgesia and Discharge Cognitive Status PHASE2COMPLETED
PET Imaging of Brain Peripheral Benzodiazepine Receptors PHASE1COMPLETED
PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28 PHASE1COMPLETED
Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T EARLY_PHASE1UNKNOWN
MEG Study of Acute STX209 Effects in ASD EARLY_PHASE1COMPLETED
Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression EARLY_PHASE1RECRUITING
Cenobamate Efficacy in Individuals With Autoimmune Epilepsy nanENROLLING_BY_INVITATION
GABA Biomarkers in Dravet Syndrome nanRECRUITING
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery. nanCOMPLETED
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy nanUNKNOWN
GABRA2 and the Pharmacokinetics of Risk for Alcoholism (GPRA) nanCOMPLETED
Oral Pregabalin Premedication for Postoperative Pain Relief nanUNKNOWN
Remifentanil and Remimazolam to Limit Patient Movement nanRECRUITING
Assessment of Peripheral GABA Receptors for Local Pain Relief nanUNKNOWN
Brain Changes in Patients With Focal Hand Dystonia nanCOMPLETED
Effects of Flumazenil on Brain Excitability nanCOMPLETED
Mechanisms of Human Plasticity in the Human System nanCOMPLETED
Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk nanCOMPLETED
Protocol Assessment of Motor Cortex rTMS for Treating Neuropathic Pain nanRECRUITING
Functional Study of Inhibitory Neurotransmission in the Human Epileptic Brain. nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a GABRA2 binder may also engage these)

ProteinNameSimilarity
P23576 — 1.000 P23576 →
Q5RCC5 — 1.000 Q5RCC5 →
P10063 — 1.000 P10063 →
P26048 — 1.000 P26048 →
GABRA5 Gamma-aminobutyric acid receptor subunit alpha-5 0.970 landscape →
Q8BHJ7 — 0.968 Q8BHJ7 →
P62813 — 0.968 P62813 →
P19969 — 0.968 P19969 →
P63080 — 0.967 P63080 →
P08219 — 0.967 P08219 →
Q4R534 — 0.967 Q4R534 →
P62812 — 0.966 P62812 →
GABRB3 Gamma-aminobutyric acid receptor subunit beta-3 0.965 landscape →
P19150 — 0.965 P19150 →
P63079 — 0.965 P63079 →
P63138 — 0.963 P63138 →
P19019 — 0.963 P19019 →
Q5R6B2 — 0.962 Q5R6B2 →
Q08E50 — 0.962 Q08E50 →
GABRA1 Gamma-aminobutyric acid receptor subunit alpha-1 0.961 landscape →
P0C2W5 — 0.959 P0C2W5 →
P15431 — 0.958 P15431 →
P50571 — 0.957 P50571 →
P08220 — 0.956 P08220 →
GABRB1 Gamma-aminobutyric acid receptor subunit beta-1 0.954 landscape →
GABRG3 Gamma-aminobutyric acid receptor subunit gamm 0.945 landscape →
P27681 — 0.943 P27681 →
P28473 — 0.942 P28473 →
D1LYT2 — 0.936 D1LYT2 →
GABRB2 Gamma-aminobutyric acid receptor subunit beta-2 0.934 landscape →