Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 7/20 | 0.57 |
| ▸ | PDPK1 | O15530 | 9/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14377085 | 0.90 | ALK (0.56) | ALKPDPK1 | |
| SCHEMBL14377766 | 0.88 | RIPK1 (0.47) | ALKKITNTRK1 | |
| SCHEMBL15842984 | 0.88 | ALK (0.60) | ALKPDPK1KITNTRK1 | |
| SCHEMBL14377786 | 0.85 | ALK (0.51) | ALKPDPK1 | |
| SCHEMBL14378200 | 0.85 | ALK (0.53) | ALKPDPK1 | |
| SCHEMBL14335646 | 0.81 | ALK (0.53) | ALKPDPK1 | |
| SCHEMBL14378180 | 0.81 | ALK (0.56) | ALKPDPK1 | |
| SCHEMBL14377787 | 0.81 | ALK (0.48) | ALKPDPK1 | |
| SCHEMBL15842457 | 0.81 | ALK (0.56) | ALKPDPK1KIT | |
| SCHEMBL14377083 | 0.80 | ALK (0.49) | ALKPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012175168-A1 | 7-AZAINDOLE DERIVATIVES SUITABLE FOR TREATMENT OF CANCERS | MERCK PATENT GMBH (DE) | 2012-12-27 | — | — | WO | disclosed |