Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | HPGDS | O60760 | 8/20 | 0.48 |
| ▸ | PDE2A | O00408 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14377374 | 0.88 | HPGDS (0.45) | NR1H4HPGDSPDE2AMEN1LMNA | |
| SCHEMBL1644658 | 0.85 | NR1H4 (0.46) | NR1H4HPGDSPDE2AMEN1LMNA | |
| SCHEMBL1285415 | 0.85 | NR1H4 (0.46) | NR1H4HPGDSLMNAPHGDH | |
| SCHEMBL1644700 | 0.80 | HPGDS (0.42) | NR1H4HPGDSPDE2AMEN1LMNA | |
| SCHEMBL1645222 | 0.80 | HPGDS (0.43) | NR1H4HPGDSPDE2AMEN1LMNA | |
| SCHEMBL1284733 | 0.80 | TRPV1 (0.42) | NR1H4HPGDSPDE2ATRPV1 | |
| SCHEMBL1285312 | 0.79 | HPGDS (0.43) | NR1H4HPGDSTRPV1 | |
| SCHEMBL14377430 | 0.79 | HPGDS (0.44) | HPGDSPDE2A | |
| SCHEMBL264499 | 0.76 | HPGDS (0.44) | HPGDSMEN1LMNAMAPK1KMT2A | |
| SCHEMBL14377396 | 0.76 | HPGDS (0.48) | HPGDSPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007133637-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2007-11-22 | — | — | WO | disclosed |