Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5218689 | 0.87 | MKNK1 (0.44) | MKNK1GRM4KDM4EALDH1A1MAPT | |
| SCHEMBL30795898 | 0.75 | GRM5 (0.62) | MKNK1GRM4GRM5 | |
| SCHEMBL3924775 | 0.75 | GRM5 (0.62) | MKNK1GRM4GRM5 | |
| SCHEMBL5215503 | 0.73 | GRM4 (0.53) | MKNK1GRM4MAPTGRM2HTR2B | |
| SCHEMBL5220141 | 0.72 | ACP1 (0.45) | MKNK1GRM4KDM4EALDH1A1MAPT | |
| SCHEMBL27914382 | 0.70 | ACHE (0.58) | KDM4ELMNASMN1; SMN2HPGD | |
| SCHEMBL5215415 | 0.70 | GRM2 (0.43) | MKNK1GRM4KDM4EALDH1A1MAPT | |
| SCHEMBL5215762 | 0.68 | AHR (0.49) | GRM4KDM4EALDH1A1MAPTLMNA | |
| SCHEMBL29590420 | 0.68 | GRM5 (0.46) | MKNK1GRM4ALDH1A1MAPTGRM5 | |
| SCHEMBL27090940 | 0.68 | GRM5 (0.46) | MKNK1GRM4ALDH1A1MAPTGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458383-B1 | HETEROARYL SUBSTITUTED PYRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2007-11-21 | — | — | EP | disclosed |