Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MPI | P34949 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12123859 | 0.90 | ALDH1A1 (0.60) | ALDH1A1MAPTTP53ALDH3A1HTT | |
| SCHEMBL12123605 | 0.88 | ALDH1A1 (0.57) | ALDH1A1MAPTTP53HTTL3MBTL1 | |
| SCHEMBL9512833 | 0.80 | ALDH1A1 (0.84) | ALDH1A1MAPTTP53ALDH3A1HTT | |
| SCHEMBL12123865 | 0.80 | ALDH1A1 (0.65) | ALDH1A1MAPTTP53ALDH3A1HTT | |
| SCHEMBL12123765 | 0.80 | ALDH1A1 (0.69) | ALDH1A1MAPTTP53ALDH3A1HTT | |
| SCHEMBL14385180 | 0.79 | ALDH1A1 (0.62) | ALDH1A1MAPTTP53ALDH3A1HTT | |
| SCHEMBL12123862 | 0.79 | ALDH1A1 (0.62) | ALDH1A1MAPTTP53ALDH3A1HTT | |
| SCHEMBL12123867 | 0.79 | ALDH1A1 (0.62) | ALDH1A1MAPTTP53ALDH3A1HTT | |
| SCHEMBL14385089 | 0.77 | ALDH1A1 (0.77) | ALDH1A1MAPTTP53ALDH3A1HTT | |
| SCHEMBL15601774 | 0.76 | ALDH1A1 (0.62) | ALDH1A1MAPTTP53ALDH3A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150290200-A1 | INTRACELLULAR KINASE INHIBITORS | PHARMACYCLICS INC (US) | 2015-10-15 | — | — | US | disclosed |
| EP-2865381-A1 | ITK inhibitors for treating blood cell malignancies | Pharmacyclics, Inc. (US) | 2015-04-29 | — | — | EP | disclosed |
| US-20140080833-A1 | INTRACELLULAR KINASE INHIBITORS | MANNKIND CORPORATION (US) | 2014-03-20 | — | — | US | disclosed |
| WO-2007136790-A2 | INTRACELLULAR KINASE INHIBITORS | MANNKIND CORPORATION (US) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150290200-A1 | INTRACELLULAR KINASE INHIBITORS | PI4KB, BTK, LTK | ALDH1A1 4370/4885MAPT 3284/4885TP53 605/4885 |
| US-20140080833-A1 | INTRACELLULAR KINASE INHIBITORS | PI4KB, BTK, LTK | ALDH1A1 4370/4885MAPT 3284/4885TP53 605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.