Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.60 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.60 |
| ▸ | TOP1 | P11387 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13545962 | 0.89 | ADORA2A (0.64) | ADORA2AADORA1ADORA2BTOP1MEN1 | |
| SCHEMBL14391010 | 0.83 | ALDH1A1 (0.43) | ADORA2AADORA1ADORA2BTOP1MEN1 | |
| SCHEMBL14390869 | 0.80 | POLB (0.49) | ADORA2AADORA1ADORA2BTOP1MEN1 | |
| SCHEMBL14392090 | 0.78 | ADORA2A (0.56) | ADORA2AADORA1ADORA2BTOP1MEN1 | |
| SCHEMBL14390997 | 0.77 | ADORA2A (0.56) | ADORA2AADORA1ADORA2BTOP1MEN1 | |
| SCHEMBL13545963 | 0.75 | ALDH1A1 (0.50) | ADORA2AADORA1ADORA2BMEN1KMT2A | |
| SCHEMBL14392093 | 0.73 | ADORA2A (0.51) | ADORA2AADORA1ADORA2BTOP1MEN1 | |
| SCHEMBL14385600 | 0.73 | KMT2A (0.56) | ADORA2AADORA1ADORA2BTOP1MEN1 | |
| SCHEMBL14391096 | 0.73 | ADORA2A (0.61) | ADORA2AADORA1ADORA2BTOP1MEN1 | |
| SCHEMBL3587811 | 0.72 | ADORA2A (0.57) | ADORA2AADORA1ADORA2BTOP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007124546-A1 | INTEGRASE INHIBITORS 3 | AVEXA LIMITED (AU) | 2007-11-08 | — | — | WO | disclosed |