Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 5/20 | 0.50 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.50 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.50 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 3/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14174877 | 0.87 | NPC1 (0.43) | GNAI3GNAO1GNAI1BCHEACHE | |
| SCHEMBL14174881 | 0.84 | GNAI3 (0.46) | GNAI3GNAO1GNAI1BCHEACHE | |
| SCHEMBL10274497 | 0.83 | GNAI3 (0.58) | GNAI3GNAO1GNAI1HSD11B1NPC1 | |
| SCHEMBL14174871 | 0.82 | NPC1 (0.62) | GNAI3GNAO1GNAI1BCHEACHE | |
| SCHEMBL8251646 | 0.82 | NPC1 (0.42) | GNAI3GNAO1GNAI1BCHEACHE | |
| SCHEMBL31749431 | 0.81 | GNAI3 (0.58) | GNAI3GNAO1GNAI1BCHEACHE | |
| SCHEMBL13773022 | 0.80 | GNAI3 (0.68) | GNAI3GNAO1GNAI1NPC1ITGB3 | |
| SCHEMBL12848033 | 0.79 | GNAI3 (0.55) | GNAI3GNAO1GNAI1HSD11B1NPC1 | |
| SCHEMBL19040869 | 0.79 | GNAI3 (0.58) | GNAI3GNAO1GNAI1BCHEACHE | |
| SCHEMBL19032708 | 0.79 | GNAI3 (0.58) | GNAI3GNAO1GNAI1BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7300936-B2 | α-(N-sulfonamido)acetamide derivatives as β-amyloid inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-11-27 | — | — | US | disclosed |