Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 2/20 | 0.42 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.42 |
| ▸ | BCL9 | O00512 | 5/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.38 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13901347 | 0.85 | JAK2 (0.44) | TRPC3TRPC7BCL9CTNNB1JAK2 | |
| SCHEMBL12953232 | 0.85 | TRPC3 (0.44) | TRPC3TRPC7BCL9CTNNB1JAK2 | |
| SCHEMBL12953214 | 0.80 | JAK2 (0.45) | TRPC3TRPC7BCL9CTNNB1JAK2 | |
| SCHEMBL13305058 | 0.77 | TRPC3 (0.57) | TRPC3TRPC7PDE4BENPP2NPC1 | |
| SCHEMBL13305223 | 0.77 | TRPC3 (0.44) | TRPC3TRPC7BCL9CTNNB1JAK2 | |
| SCHEMBL13305054 | 0.77 | TRPC3 (0.53) | TRPC3TRPC7PDE4BUSP30ENPP2 | |
| SCHEMBL13901233 | 0.76 | JAK2 (0.46) | TRPC3TRPC7BCL9CTNNB1JAK2 | |
| SCHEMBL12953919 | 0.75 | TRPC3 (0.53) | TRPC3TRPC7JAK2JAK1TYK2 | |
| SCHEMBL12953546 | 0.75 | TRPC3 (0.53) | TRPC3TRPC7USP30ENPP2NPC1 | |
| SCHEMBL13901344 | 0.75 | TRPC3 (0.53) | TRPC3TRPC7JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534710-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2007-10-24 | — | — | EP | disclosed |